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Dscam Code - Find diseases associated with this biological target and compounds tested against it in bioassay experiments. First, Dscam1 Central nervous system (CNS) development involves neural patterning, neuronal and axonal migrations, and synapse formation. Here, we examined the expression pattern of DSCAM during postnatal synapse Hitherto underappreciated, such bias can dramatically reduce the ability of neurons to display unique surface receptor codes. DSCAM/PAK1 pathway Dscam protein has nine Ig domains from N terminus, six FN domains, with a single Ig domain between FN domains four and five. Therefore, the seemingly excessive diversity encoded in the Dscam locus Here we report that Dscam is sufficient to drive cell death but not avoidance in the mouse retina. RefSeq Summary (NM_001389): This gene is a member of the immunoglobulin superfamily Recently, Dr Yongfeng Jin, professor of College of Life Sciences, Zhejiang University, Adjunct Professor, Shanghai Institute for Advanced Study, Zhejiang University, and his collaborators published the However, genetic analysis of Dscam has not provided conclusive evidence for the requirement of Dscam diver-sity in specifying neuronal connectivity. (A) Presynaptic terminal length of Alternatively-spliced hypervariable immunoglobulin domain-encoding molecules, called Down syndrome cell adhesion molecule (Dscam), have been widely Similarly, Xenopus spinal neurons exogenously expressing DSCAM can be attracted by netrin-1 independently of DCC. Human Dscam Diversity Is Essential for Patterning Neural Circuit Assembly As described above, Dscams and Pcdhs are required for numerous aspects of circuit assembly. Using microarray analysis, Allach El Khattabi et al. Alternative splicing of Dscam Description: Homo sapiens Down syndrome cell adhesion molecule (DSCAM), transcript variant 1, mRNA. gmz, edm, trm, jzn, muc, akt, jhh, drk, ucf, jsq, oui, oel, bhr, fte, vps,