What is a normal elf score. 7 to 9. It is indicated as a prognostic marker in conjunction with other laboratory findings and clinical assessments in patients with advanced fibrosis (F3 or F4) due to nonalcoholic In community pathways for detection of liver disease the most common reason for referral is fibrosis assessment. noninvasive blood test requiring a single nonfasting tube of serum, the ELF Score is based on 3 direct markers of fibrosis: As per the locally agreed primary care pathway, the ELF test should be considered for the assessment of liver fibrosis in adult patients with NAFLD. 7–10 ELF is included as a Background and aims: The enhanced liver fibrosis (ELF) score is a blood test that combines three markers linked to liver fibrosis. 51, then advanced liver fibrosis is unlikely. 8 and were significantly higher for men vs. The ELF score has been assessed in a number of studies and has shown comparable accuracy with the Fibroscan. The ELF Score can help identify patients with advanced fibrosis (F3 or F4) at risk of progressing to cirrhosis and liver-related events (LREs). The ELF score measures the proteins involved in the scarring process itself. If ELF Score <10. The ELF score can predict moderate fibrosis and cirrhosis. The ELF Score is recommended by AACE guidelines,6 as its measurements have proven valuable for identifying patients with advanced fibrosis (F3 or F4) at risk of progressing to cirrhosis and liver-related events. If the ELF Score is <10. Both the ELF score and Fibroscan can better predict a patient’s long-term survival than a biopsy alone. Discover how this non-invasive blood test assesses liver health and risk. 6. 9 vs. The three direct markers of the ELF Test are complementary and, when combined into an ELF score, provide information that is prognostic for progression to cirrhosis and liver-related events. The ELF Score is the first noninvasive biomarker blood test for prognostic risk assessment in advanced MASH. The ELF Score can be used as a prognostic marker for patients who need urgent specialized intervention. 51 then retest in 3 years (repeat requests made within this time frame will be rejected by the clinical biochemistry laboratory). . The Enhanced Liver Fibrosis (ELF) score is an ECM marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease. 3 1, 3 The sensitivity of ELF score >11. Aug 1, 2013 · ELF score reference values ranged from 6. 3, respectively). 5, respectively). Age was a notable influence factor. The performance of the ELF Test has been well-established in the scientific literature, and ease of testing and interpretation support routine clinical use. The ELF score consisting of single markers of hepatic matrix metabolism is one of the first commercially available serum mul-timarker fibrosis tests. Jul 18, 2025 · The ELF score represents an important advance in non-invasive assessment of liver fibrosis that can help identify patients at risk for disease progression and adverse outcomes. This distinction matters because you can have significant fibrosis with completely normal liver enzymes. ELF Score ≥10. Afternoon values were slightly higher than morning values (6. An ELF Score ≥10. 8. Sample type: serum sample Turn-around time: within 2 weeks Aug 1, 2013 · The ELF score consisting of single markers of hepatic matrix metabolism is one of the first commercially available serum multimarker fibrosis tests. Understanding what is the normal range for the elf test is crucial, as the score's primary use is to determine the risk of advanced liver fibrosis, not as a simple diagnostic tool. 7–9. However, there is a need for independent validation of the ELF score with regard to validated reference values, influencing factors and suitable cut-off values. women (7. 51 suggests advanced liver fibrosis and is an indication for referral to a specialist in hepatology. 51 suggests advanced liver fibrosis and is an indication for referral to Hepatology clinic. 0–9. Nov 8, 2025 · Studies of healthy individuals show that a reference range for the Enhanced Liver Fibrosis (ELF) score typically falls between approximately 6. The Enhanced Liver Fibrosis (ELF) Score is a noninvasive test that indicates whether a patient with NASH and advanced fibrosis has a higher or lower risk of disease progression to cirrhosis (for those with F3 fibrosis) or other liver-related clinical events (for those with F3 or F4 fibrosis) within 1 to 4 years. 7 and 9. 3 for diagnosing cirrhosis is approximately 83% with a specificity of 97% 3 The Enhanced Liver Fibrosis (ELF™) blood test is a simple, accurate, non-invasive test that provides a simple, unitless numeric score that is generated via an algorithm for use in advanced liver fibrosis. The utility of the ELF score has been demonstrated primarily in Western countries, but whether it is useful in areas Oct 14, 2025 · An ELF score of 11. However, there is a need for independent validation of the ELF score with regard to validated reference val-ues, influencing factors and suitable cut-off values. We investigated the impact of adding the Enhanced Liver Fibrosis (ELF) score as a second-line test (subsequent to an indeterminate or high Fibrosis-4 index [FIB-4] and/or non-alcoholic fatty liver disease fibrosis score) to guide referral and prognostication in our multi-aetiology Nov 8, 2025 · Learn about the Enhanced Liver Fibrosis (ELF) score, including what is the normal range for the ELF score. However, influence factors such as gender and age need to be taken into account. 6–9. 53 falls within the range typically associated with cirrhosis (F4), which is generally considered to be >11. vgdx vpvldqh ecatms taefj sixxct isw edhz rvjek ixumc vcjw